Effects of probenecid on the pharmacokinetics of allopurinol riboside.
نویسندگان
چکیده
Allopurinol riboside is an experimental agent for the treatment of leishmaniasis and American trypanosomiasis. Previous studies showed that after oral administration, unexpectedly low levels of allopurinol riboside in plasma are attributable to incomplete absorption and rapid renal clearance. In this randomized, crossover evaluation in healthy volunteers, probenecid reduces the renal clearance of allopurinol riboside, extends the half-life of allopurinol riboside in plasma, and triples the levels of allopurinol riboside in plasma.
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عنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 37 5 شماره
صفحات -
تاریخ انتشار 1993